BtBs seminario – Integrative Antibody Discovery for Challenging Protein Aggregates.

Seminario – Biotecnologie e Bioscienze – Giovedì 10 ottobre 2024, ore 16:30, edificio U3-BIOS, aula U3-08

Protein aggregation drives neurodegeneration, but studying this process is challenging due to the structural and chemical diversity of the aggregates. While antibodies are valuable research tools, they often struggle to bind specifically to these diverse protein species. To address this, we developed an antibody discovery platform that combines protein design and directed evolution, expanding the repertoire of target biomolecules. Our approach generated antibodies that specifically target amyloid-beta and alpha-synuclein toxic aggregates, key in Alzheimer’s and Parkinson’s. Our results provide insights into the mechanisms of these pathologies and identify potential therapeutic targets.

Il seminario è aperto a tutti

per informazioni:  infobtbs@unimib.it